In recent years there has been a tremendous surge in the general capabilities of AI systems, mainly fuelled by training foundation models on internet-scale data. Nevertheless, the creation of open-ended, ever self-improving AI remains elusive. In this position paper, we argue that the ingredients are now in place to achieve open-endedness in AI systems with respect to a human observer. Furthermore, we claim that such open-endedness is an essential property of any artificial superhuman intelligence (ASI). We begin by providing a concrete formal definition of open-endedness through the lens of novelty and learnability. We then illustrate a path towards ASI via open-ended systems built on top of foundation models, capable of making novel, human-relevant discoveries. We conclude by examining the safety implications of generally-capable open-ended AI. We expect that open-ended foundation models will prove to be an increasingly fertile and safety-critical area of research in the near future.