Position: The Age of AI Agents Demands A New Scientific Paradigm To Sustain Trustworthy Science

AI systems are becoming autonomous research agents that generate hypotheses, design experiments, and produce discoveries at scales beyond human oversight. As seen by increased submissions to ML venues, the verification gap between scientific output and our ability to check it is already widening, and autonomous agents make it worse by magnitudes given human-agent asymmetry. We argue that science must evolve its verification infrastructure, as it has before with peer review. However, while historical adaptations assumed human contributors who could be questioned and sanctioned, AI agents break this assumption. We propose criteria for an adapted verification infrastructure that emphasizes observable-by-default workflows, scalable verification, and clear attribution. We argue that without adaptation, ML and any scientific domain using agents face dangerous failures: experimental results that no person can verify, optimization for metrics over understanding, and accountability vacuums that erode scientific trust.