Aggregation of Multiple Knockoffs
Tuan-Binh Nguyen · Jerome-Alexis Chevalier · Thirion Bertrand · Sylvain Arlot
Keywords:
Computational Biology and Genomics
Neuroscience and Cognitive Science
Robust Statistics and Machine Learning
Supervised Learning
Boosting / Ensemble Methods
2020 Poster
Abstract
We develop an extension of the knockoff inference procedure, introduced by Barber & Candes (2015). This new method, called Aggregation of Multiple Knockoffs (AKO), addresses the instability inherent to the random nature of knockoff-based inference. Specifically, AKO improves both the stability and power compared with the original knockoff algorithm while still maintaining guarantees for false discovery rate control. We provide a new inference procedure, prove its core properties, and demonstrate its benefits in a set of experiments on synthetic and real datasets.
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