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Poster
in
Workshop: Interpretable Machine Learning in Healthcare

Learning sparse symbolic policies for sepsis treatment

Jacob Pettit · Brenden Petersen · Leno da Silva · Gary An · Daniel Faissol


Abstract:

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite its severity, no FDA-approved drug treatments exists. Recent work controlling sepsis simulations with deep reinforcement learning have successfully discovered effective cytokine mediation strategies. However, the performance of these neural-network based policies comes at the expense of their deployability in clinical settings, where sparsity and interpretability are required characteristics. To this end, we propose a pipeline to learn simple, sparse symbolic policies represented by constants and/or succinct, human-readable expressions. We demonstrate our approach by learning a sparse symbolic policy that is efficacious on simulated sepsis patients.

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