Non-stationary environments are challenging for reinforcement learning algorithms. If the state transition and/or reward functions change based on latent factors, the agent is effectively tasked with optimizing a behavior that maximizes performance over a possibly infinite random sequence of Markov Decision Processes (MDPs), each of which drawn from some unknown distribution. We call each such MDP a context. We introduce an algorithm that analyzes a possibly infinite stream of data and computes, in real-time, high-confidence change-point detection statistics that reflect whether novel, specialized policies need to be created and deployed to tackle novel contexts, or whether previously-optimized ones might be reused. We show that (i) this algorithm minimizes the delay until unforeseen changes to a context are detected, thereby allowing for rapid responses; and (ii) it bounds the rate of false alarm, which is important in order to minimize regret.