We introduce topological mixture estimation, a completely nonparametric and computationally efficient solution to the problem of estimating a one-dimensional mixture with generic unimodal components. We repeatedly perturb the unimodal decomposition of Baryshnikov and Ghrist to produce a topologically and information-theoretically optimal unimodal mixture. We also detail a smoothing process that optimally exploits topological persistence of the unimodal category in a natural way when working directly with sample data. Finally, we illustrate these techniques through examples.